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If you start off with one molecule of water, you have to divide by Avogadro's number to convert the molecule to moles, and then you can multiply the mole by the molar mass of water to get grams. So you should end up with 2.991 x 10^-23 g/molecule. Does that make sense?
Find the weight of 1 mole of water. Remember each mole of a substance contains exactly 6.022*10^23 molecules of that substance. Therefore the weight of a mole of water divided by 6.022*10^23 would equal the weight of 1 water molecule.
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