axial/equatorial positions for multiple substituents

[Wendy_Liu_3A]

To ensure the highest stability, we put substituents on the equatorial positions. What I'm unsure is, when there are two substituents adjacent to each other, do we put both of them in equatorial positions?

What if there are multiple substituents - can I put all of them in equatorial positions if cis/trans is not specified? Thank you!

[Michelle_Tan_1G]

When you say adjacent to each other, do you mean on the same C atom? In that case, one would be axial and one equatorial. Otherwise, the more complex/heavier atom is put in the equatorial position. I think it's because it is more likely to be unstable/produce stronger repulsions.

[Wendy_Liu_3A]

Sorry I meant to say, they are on different atoms but next to each other. If you look at problem set #1, viewtopic.php?f=88&t=20700&p=59306&hilit=problem+set&sid=1a75ec9167f0318e98a48d5e305b4b6a#p59306, some substituents are attached to different carbon next to each other but one is axial while the other is equatorial...