Determining highest-priority groups in isomers

[allielee]

How do you determine which two groups in a molecule are the ones to compare in order to determine cis and trans formation?

[Lillian Xie 1K]

If there are multiple higher bonds, you need to identify whether each of them are cis/trans or E/Z. You tell your audience which bond is which in the beginning by listing the specifications in order respective to that in which the higher order bonds are listed.

[Erin Natale 3I]

You should also be looking at the groups that are across a double bond.