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Biological examples of co-ordination compounds

Posted: Sun Dec 01, 2019 5:00 pm
by Dakota Walker 1L
Do we need to know specific examples and how they work for the final?
If so does anyone know which specific molecules we need to memorize?

Re: Biological examples of co-ordination compounds

Posted: Sun Dec 01, 2019 5:09 pm
by Andrew Jang 4D
I feel like being conceptually aware of the significance of coordination compounds in biology will be more useful than memorizing specific examples. I do remember him talking about cisplatin and how it's an important chemo drug as it forms a coordination compound w/ DNA to stop replication.

Re: Biological examples of co-ordination compounds

Posted: Sun Dec 01, 2019 5:15 pm
by gabbymaraziti
Prof. Lavelle did spend a significant amount of time on cisplatin, so I think we should understand that and the distinction between cis and trans.

Re: Biological examples of co-ordination compounds

Posted: Sun Dec 01, 2019 5:16 pm
by EMurphy_2L
what we've talked about is
-cisplatin (chemo drug in which only cis- molecule, not trans- will connect)
-myglobin (square planar N with Fe + protein surrounding it)
-hemoglobin (4 myoglobin-like molecules)

and he put on the board these transition metals:
-chromin (assists insulin in controlling blood sugar)
-iron (electron transfer in oxidation of organic molecules, respiratory chain)
-cobalt (vitamin B12)
-Mn, Ni, Cu, Zn (enzyme function)