Chemotherapy

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Jarrett Peyrefitte 2K
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Chemotherapy

Postby Jarrett Peyrefitte 2K » Sat Dec 07, 2019 3:36 pm

What are well-known examples of coordination compounds used as chemotherapy drugs?

Ethan Lam 4A
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Re: Chemotherapy

Postby Ethan Lam 4A » Sat Dec 07, 2019 3:43 pm

Cisplatin is an example of a chemotherapy drug that stops cancer.

Mai V 4L
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Re: Chemotherapy

Postby Mai V 4L » Sun Dec 08, 2019 9:20 am

Will this be on the final?

Brianna Becerra 1B
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Re: Chemotherapy

Postby Brianna Becerra 1B » Sun Dec 08, 2019 4:09 pm

Cisplatin is used as a chemotherapy drug as the Cl binds to DNA as it is substituting two adjacent guanines.

Haley Pham 4I
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Re: Chemotherapy

Postby Haley Pham 4I » Sun Dec 08, 2019 4:52 pm

Cisplatin is a chemotherapy drug that binds to DNA by substituting Cl for two adjacent Guanines. It blocks cell division (replication), which treats cancer.

Annie Ye
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Re: Chemotherapy

Postby Annie Ye » Sun Dec 08, 2019 6:31 pm

Cisplatin is an example of a chemoterapy drug. It binds to the Guanine in DNA and stops replication. Transplatin is not effective because it only forms one bond with DNA.

Adam Bustamante 1I
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Re: Chemotherapy

Postby Adam Bustamante 1I » Thu Dec 10, 2020 9:01 am

cisplatin is the chemotherapy drug mentioned in lecture. it binds to the DNA and the two adjacent guanines.

SelenaDahabreh1D
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Re: Chemotherapy

Postby SelenaDahabreh1D » Thu Dec 10, 2020 9:05 am

Mai V 4L wrote:On almost every UA sheet from Week 9, there was a question about cisplatin. I think Dr. Lavelle spent a significant amount of time explaining cisplatin (and transplatin), so I would expect it to show up on the final in one way or another.
On almost every UA sheet from Week 9, there was a question about cisplatin. I think Dr. Lavelle spent a significant amount of time explaining cisplatin (and transplatin), so I would expect it to show up on the final in one way or another.

Edwin Liang 1I
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Re: Chemotherapy

Postby Edwin Liang 1I » Fri Dec 11, 2020 2:10 pm

As mentioned in lecture, cisplatin is one of them.

Simi Kapila_3E
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Re: Chemotherapy

Postby Simi Kapila_3E » Fri Dec 11, 2020 2:12 pm

The only one I remember being in his lecture was cisplatin. And on the course outline it says we should know chemotherapy drugs, so it might be helpful to remember this for the final.

Kyla Roche 2K
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Re: Chemotherapy

Postby Kyla Roche 2K » Fri Dec 11, 2020 2:33 pm

Cisplatin is the drug that prohibits the replications of cells. This is because the CIS- means same side for a molecule opposed to trans- which means opposite sides.

Jade_Tai_2L
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Re: Chemotherapy

Postby Jade_Tai_2L » Fri Dec 11, 2020 4:04 pm

I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?

SophiaJenny3I
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Re: Chemotherapy

Postby SophiaJenny3I » Fri Dec 11, 2020 4:42 pm

Jade_Tai_2L wrote:I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?


I'm pretty sure the only one we'd have to know is cisplatin, and possibly why transplatin is its ineffective counterpart.

simona_krasnegor_1C
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Re: Chemotherapy

Postby simona_krasnegor_1C » Sat Dec 12, 2020 6:57 pm

cisplatin was the one discussed in lecture!

AnjikaFriedman-Jha2D
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Re: Chemotherapy

Postby AnjikaFriedman-Jha2D » Sun Dec 13, 2020 9:19 am

I think cisplatin Is the only one we would need to know and it is significant because both chlorines are on the same side of the complex, cis, which allows it to form two bonds with Guanine to stop DNA replication of cancer cells

Mia Meza
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Re: Chemotherapy

Postby Mia Meza » Sun Dec 13, 2020 10:12 am

I know cisplatin is what Lavelle mentioned because Cl binds with Guanine to prevent the cancer cells from replicating.

Mia Meza
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Re: Chemotherapy

Postby Mia Meza » Sun Dec 13, 2020 10:16 am

SophiaJenny1J wrote:
Jade_Tai_2L wrote:I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?


I'm pretty sure the only one we'd have to know is cisplatin, and possibly why transplatin is its ineffective counterpart.



I know for transplatin it is ineffective because of the geometry (correct me if I am wrong). Cisplatin has Cl- on the same side while Transplatin has Cl- on opposite sides therefore making it ineffective

Inderpal Singh 2L
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Re: Chemotherapy

Postby Inderpal Singh 2L » Tue Dec 15, 2020 2:36 pm

Why do cisplatin and transplatin behave differently?

Nancy Yao
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Re: Chemotherapy

Postby Nancy Yao » Wed Dec 16, 2020 5:58 am

Mia Meza wrote:
SophiaJenny1J wrote:
Jade_Tai_2L wrote:I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?


I'm pretty sure the only one we'd have to know is cisplatin, and possibly why transplatin is its ineffective counterpart.



I know for transplatin it is ineffective because of the geometry (correct me if I am wrong). Cisplatin has Cl- on the same side while Transplatin has Cl- on opposite sides therefore making it ineffective


That's very interesting.


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