Chemotherapy

[Jarrett Peyrefitte 2K]

What are well-known examples of coordination compounds used as chemotherapy drugs?

[Ethan Lam 4A]

Cisplatin is an example of a chemotherapy drug that stops cancer.

[Mai V 4L]

Will this be on the final?

[Brianna Becerra 1B]

Cisplatin is used as a chemotherapy drug as the Cl binds to DNA as it is substituting two adjacent guanines.

[Haley Pham 4I]

Cisplatin is a chemotherapy drug that binds to DNA by substituting Cl for two adjacent Guanines. It blocks cell division (replication), which treats cancer.

[Annie Ye]

Cisplatin is an example of a chemoterapy drug. It binds to the Guanine in DNA and stops replication. Transplatin is not effective because it only forms one bond with DNA.

[Adam Bustamante 1I]

cisplatin is the chemotherapy drug mentioned in lecture. it binds to the DNA and the two adjacent guanines.

[SelenaDahabreh1D]

On almost every UA sheet from Week 9, there was a question about cisplatin. I think Dr. Lavelle spent a significant amount of time explaining cisplatin (and transplatin), so I would expect it to show up on the final in one way or another.

On almost every UA sheet from Week 9, there was a question about cisplatin. I think Dr. Lavelle spent a significant amount of time explaining cisplatin (and transplatin), so I would expect it to show up on the final in one way or another.

[Edwin Liang 1I]

As mentioned in lecture, cisplatin is one of them.

[Simi Kapila_3E]

The only one I remember being in his lecture was cisplatin. And on the course outline it says we should know chemotherapy drugs, so it might be helpful to remember this for the final.

[Kyla Roche 2K]

Cisplatin is the drug that prohibits the replications of cells. This is because the CIS- means same side for a molecule opposed to trans- which means opposite sides.

[Jade_Tai_2L]

I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?

[SophiaJenny3I]

I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?

I'm pretty sure the only one we'd have to know is cisplatin, and possibly why transplatin is its ineffective counterpart.

[simona_krasnegor_1C]

cisplatin was the one discussed in lecture!

[AnjikaFriedman-Jha2D]

I think cisplatin Is the only one we would need to know and it is significant because both chlorines are on the same side of the complex, cis, which allows it to form two bonds with Guanine to stop DNA replication of cancer cells

[Mia Meza]

I know cisplatin is what Lavelle mentioned because Cl binds with Guanine to prevent the cancer cells from replicating.

[Mia Meza]

I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?

I'm pretty sure the only one we'd have to know is cisplatin, and possibly why transplatin is its ineffective counterpart.

I know for transplatin it is ineffective because of the geometry (correct me if I am wrong). Cisplatin has Cl- on the same side while Transplatin has Cl- on opposite sides therefore making it ineffective

[Inderpal Singh 2L]

Why do cisplatin and transplatin behave differently?

[Nancy Yao]

I only remember Dr. Lavelle going over Cisplatin-- do we have to know others?

I'm pretty sure the only one we'd have to know is cisplatin, and possibly why transplatin is its ineffective counterpart.

I know for transplatin it is ineffective because of the geometry (correct me if I am wrong). Cisplatin has Cl- on the same side while Transplatin has Cl- on opposite sides therefore making it ineffective

That's very interesting.

[Bobak Pourrahimi 2L]

Cisplatin and transplatin behave differently because of the different placement of Cl in the structure of the compound. Since cisplatin has both Cl on one side, it can bind to the DNA properly. Transplatin has the Cl on opposite sides of the compound, causing it to be incapable of properly binding to DNA.

[Ainsley McCabe 2D]

Will this be on the final?

I would assume so because Lavelle stressed it heavily in our lecture.

[Tony Chen 1F]

It's good to know the difference between cisplatin and translation and especially why cisplatin can be used in chemotherapy while transplatin cannot (because Cl is on opposite sides of each other so they cannot bind to two sites in the DNA)

[Terrence Chi]

Hi, I remember Lavelle discussing chemotherapy and mentioning cisplatin during one of the lectures. Cisplatin binds with guanine in the DNA to stop the cancer cells from replicating. Hope this help!