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That would depend on the values of those variables. If the value of temperature multiplied by entropy is greater than the value of enthalpy, then your sign for Gibbs Free Energy will be negative and vice versa for a positive value.
If such problem were to arise, you would need to be given specific values for enthalpy, temperature, and entropy in order to find the sign of Gibbs Free Energy. Either that, or you would need to be given some means to find those values. Without that information you would be unable to determine the sign based on the formula alone.
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