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I think you're talking about the differential rate laws because for the first order rate law, you just have to work with initial and final concentration, one of which is usually given to you. But for the differential rate laws, which I think the question is referring to, then yes you have to always use reactant concentrations.
I think that reactant concentrations will always be used unless the reverse reaction is used! (so technically the products are now the reactants)
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