## Enzymes

$V_{0} = \frac{V_{max}[S]}{K_{M} + [S]}; K_{M} = \frac{[E][S]}{[ES]}$

Hector Acosta Discussion 1H
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Joined: Fri Sep 29, 2017 7:04 am

### Enzymes

I know enzymes and catalysis make the activation energy lower, which makes the rate faster. But why and how do they do this? And can someone give an example.

Victoria Draper 1G
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### Re: Enzymes

Enzymes are proteins functioning as catalysts that speed up reactions by lowering the activation energy. A simple and succinct definition of an enzyme is that it is a biological catalyst that accelerates a chemical reaction without altering its equilibrium. Amylase is an example of an enzyme that breaks down starches into sugars.

Phi Phi Do 2E
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### Re: Enzymes

enzymes generally lower the activation energy because it would decrease the energy barrier that needs to be overcome in order for the reaction to begin. Thehrefore, because enzymes increase reaction rate, the activation energy is lowered for it to do so.

Cyianna 2F
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### Re: Enzymes

Right, enzymes are a type of catalyst that lower activation energy so the rate is faster.

K Stefanescu 2I
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### Re: Enzymes

This is a very basic model of an enzyme in action: https://www.youtube.com/watch?v=V4OPO6JQLOE (It's a short video and has pretty nifty animation.)
This demonstrates one way that enzymes can lower the activation energy, in this case by bringing the substrates together in the correct orientation so they can react more readily.
Other methods of decreasing activation energy include distorting substrate bonds or providing/acting on the substrate(s) using a completely different pathway that happens to have a lower activation energy.

Chris Lamb 1G
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### Re: Enzymes

We learned about mechanisms earlier. Some enzymes (maybe even all enzymes) lower the energy by creating a different mechanism for the reaction. This new mechanism has a smaller energy barrier.

Rana YT 2L
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### Re: Enzymes

the most basic understanding is that enzymes make the reaction faster by providing a different pathway in which the activation energy is lower

Jason Ye 2I
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### Re: Enzymes

Enzymes have activation sites that fit substrates in and make reactions faster.

Carine Tamamian 2B
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### Re: Enzymes

Enzymes lower the activation energy.