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First, keep in mind that for Heisenberg's uncertainty principle, means "indeterminacy in" or "Uncertainty in" NOT "change in". Generally, questions will ask for the minimum uncertainty, and so an equal sign can be used. But the formula itself does use a sign.
It starts to matter as we research more into phenomenon of quantum mechanics and find uses for quantum mechanic application. This criterion sets a limitation to which scientists can achieve accuracy and applies to all other objects, not just electrons.
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