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Kayla Maldonado 1C
Posts: 107
Joined: Sat Aug 17, 2019 12:16 am
Been upvoted: 1 time


Postby Kayla Maldonado 1C » Sat Dec 07, 2019 11:03 pm

What else besides knowing that the Cl atoms in cisplatin can attach to DNA bases to initiate cell death in chemotherapy is necessary to know about cisplatin?

Lilyana Villa 1J
Posts: 50
Joined: Sat Aug 17, 2019 12:15 am

Re: Cisplatin

Postby Lilyana Villa 1J » Sat Dec 07, 2019 11:10 pm

All you really need to know is just that cisplatin is a chemotherapy drug whose two Cl ligands bind to guanine in order to prevent the DNA polymerase from attaching to guanine. So pretty much exactly what you said.

Kaylee Sepulveda 4G
Posts: 100
Joined: Thu Jul 11, 2019 12:16 am

Re: Cisplatin

Postby Kaylee Sepulveda 4G » Sat Dec 07, 2019 11:37 pm

Another thing to note is that cisplatin is effective and transplatin is not because a cisplatin molecule has chlorines on the same side, which can bond with two adjacent guanines. This creates a stronger hold, and prevents replication. Transplatin couldn't because the chlorines are on opposite sides and one chlorine bonding with one guanine is not strong enough.

Annie Ye
Posts: 106
Joined: Wed Sep 18, 2019 12:22 am

Re: Cisplatin

Postby Annie Ye » Sun Dec 08, 2019 6:15 pm

Cisplatin stops the DNA polymerase from replicating the DNA. Transplatin is weak because the DNA polymerase can knock it off.

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