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Cisplatin

Posted: Sat Dec 07, 2019 11:03 pm
by Kayla Maldonado 1C
What else besides knowing that the Cl atoms in cisplatin can attach to DNA bases to initiate cell death in chemotherapy is necessary to know about cisplatin?

Re: Cisplatin

Posted: Sat Dec 07, 2019 11:10 pm
by Lilyana Villa 3L
All you really need to know is just that cisplatin is a chemotherapy drug whose two Cl ligands bind to guanine in order to prevent the DNA polymerase from attaching to guanine. So pretty much exactly what you said.

Re: Cisplatin

Posted: Sat Dec 07, 2019 11:37 pm
by Kaylee Sepulveda 4G
Another thing to note is that cisplatin is effective and transplatin is not because a cisplatin molecule has chlorines on the same side, which can bond with two adjacent guanines. This creates a stronger hold, and prevents replication. Transplatin couldn't because the chlorines are on opposite sides and one chlorine bonding with one guanine is not strong enough.

Re: Cisplatin

Posted: Sun Dec 08, 2019 6:15 pm
by Annie Ye
Cisplatin stops the DNA polymerase from replicating the DNA. Transplatin is weak because the DNA polymerase can knock it off.