Cisplatin Drug formation

Moderators: Chem_Mod, Chem_Admin

Lusin_Yengibaryan_3B
Posts: 73
Joined: Wed Sep 30, 2020 9:33 pm

Cisplatin Drug formation

Postby Lusin_Yengibaryan_3B » Thu Nov 26, 2020 1:37 am

Why is it that in the cisplatin chemotherapy drug, the guanine strand is the one affected by the lone pair Nitrogen and not the other DNA strands? What makes guanine susceptible to this phenomenon?

Akash J 1J
Posts: 73
Joined: Wed Sep 30, 2020 9:58 pm
Been upvoted: 1 time

Re: Cisplatin Drug formation

Postby Akash J 1J » Thu Nov 26, 2020 11:23 am

My best guess is that having two adjacent guanines allows the two nitrogens with the lone pairs to be the right distance for the cisplatin drug to form the coordinate covalent bond to it.

Jiapeng Han 1C
Posts: 65
Joined: Wed Sep 30, 2020 9:50 pm

Re: Cisplatin Drug formation

Postby Jiapeng Han 1C » Sat Nov 28, 2020 7:45 am

My best guess is that cisplatin can bind to the N7 of the guanine molecule.
Check out the link below!
https://images.app.goo.gl/ZGgwc2LkrLssVM3j7

Can Yilgor 2D
Posts: 64
Joined: Wed Sep 30, 2020 10:09 pm

Re: Cisplatin Drug formation

Postby Can Yilgor 2D » Sat Nov 28, 2020 8:40 am

I guess it has something to do with the structure of the guanine nitrogenous base, but I'm not certain and I don't want to confuse anyone. You could see the below link which describes the interaction of cisplatin with DNA, but I think it's hard to understand and well beyond the scope of our course.

Hope this helps

https://www.ncbi.nlm.nih.gov/pmc/articl ... 20in%20DNA.


Return to “*Molecular Orbital Theory (Bond Order, Diamagnetism, Paramagnetism)”

Who is online

Users browsing this forum: No registered users and 1 guest