Coordination in Chemotherapy

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Ariana Morales
Posts: 29
Joined: Fri Sep 28, 2018 12:15 am

Coordination in Chemotherapy

Postby Ariana Morales » Sun Dec 02, 2018 10:38 pm

how does coordination relate to chemotherapy drugs? How can we explain them?

mahika_nayak_3L
Posts: 60
Joined: Fri Sep 28, 2018 12:26 am

Re: Coordination in Chemotherapy

Postby mahika_nayak_3L » Sun Dec 02, 2018 10:48 pm

Cisplatin is a well known chemotherapy drug and it forms a coordination complex with DNA, stopping cell division because the DNA can't be further replicated.

Jake Gordon 1A
Posts: 61
Joined: Fri Sep 28, 2018 12:15 am

Re: Coordination in Chemotherapy

Postby Jake Gordon 1A » Mon Dec 03, 2018 11:27 am

Cisplatin is the example from class. It must be cis because that means the two chlorine atoms are on the same side and they can each be replaced with water and will bond to a N with a lone pair on a guanine base. At a region of two close Guanine bases both chlorines can be replaced with water and will bind forming a stronger cisplatin-dna-complex. This attracts DNA repair proteins which irreversibly bind, this distorts the shape of dna and prohibits replication. If replication is stopped the cancer cells can't divide. This is crucial because uncontrolled cell division is the definition of cancer.


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