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Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:28 pm
by NRobbins_1K
Can someone explain the difference between cis and trans and how that applies to cisplatin?

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:29 pm
by Clarice Chui 2C
Cis means that the electronegative atoms around the central atom are all on the same side. This means it’s polar. Trans means that the atoms around the central atom are opposite each other, making it symmetrical and nonpolar. Cisplatin is a well-known chemotherapy drug that forms a coordination compound with DNA that stops cell division.

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:29 pm
by Alex Hitti 3E
cis- means that the electronegative atoms are both on one side which creates a dipole moment. meanwhile trans- means that the electronegative atoms are on opposite sides whicgh the dipole moments cancel out, thus there is no dipole moment. In regards to cis/trans-platin, the chlorine atoms are the place holders for the electronegative atoms mentioned above

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:33 pm
by MinuChoi
Adding on:
cis- means something like "on one side", and trans means "across".
cis-molecule are typically polar and trans-molecules are typically nonpolar.

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:33 pm
by KarineKim2L
Cisplatin works as a chemotherapy drug while trans-diamine-dichloro-platinum (II) does not because cisplatin is polar and therefore more reactive, and binds to the exposed Nitrogens on Guanine that result from the duplication of DNA. Cisplatin needs to bind to Guanine in 2 places for the bond to be strong enough, and therefore it is necessary for the two Cl atoms to be next to each other. This is why transplatin would not work. Unhealthy DNA that constantly divides has constantly exposed Nitrogen molecules unlike healthy DNA.

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:37 pm
by Quynh Vo
cis means the atoms are on the same side while trans means they're on opposite sides from each other. The determines if they are polar or non polar

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 8:59 pm
by Nare Nazaryan 1F
Cis means the electronegative atoms are on the same side (e.g. two chlorines), which trans is when they're on opposite sides. Cisplatin works because Guanine can displace two chlorines from one side, vs. two chlorines on opposite sides (trans).

Re: Meaning of Cis and Trans

Posted: Sun Nov 24, 2019 9:01 pm
by Kehlin Hayes 4C
Cis refers to when the atom has the dipole movements on the same side of the molecule making it polar. Trans means the dipole movements are on opposing sides cancelling out making the molecule non polar.

Re: Meaning of Cis and Trans

Posted: Fri Nov 29, 2019 11:58 pm
by Michelle N - 2C
Cis generally means when the molecules are next to each other one side, while trans generally means that they're opposite of each other, like across from each other.

This applies to cisplatin as that is a well-known chemotherapy drug that stops cell division. In other words, I think the reason why cisplatin is applied here is that the cis version is the one that's able to form a coordination compound with the DNA.

Re: Meaning of Cis and Trans

Posted: Sat Nov 30, 2019 12:26 am
by RobertXu_2J
Cis means that the molecule is symmetrical, with the same elements are on the same side. Trans means opposite, the elements are on different sides.

Re: Meaning of Cis and Trans

Posted: Sat Nov 30, 2019 1:24 pm
by erica thompson 4I
This is a generalization, but many examples we are given include more than one atom of the same type. Adding onto everyone's answers above, oftentimes the same atom (which therefore has the same electronegativity) can be a good distinguisher of cis- vs. trans-. If the same atom types are on the same side of the central atom, it is cis- and symmetrical. If the same atom types are on opposite sides of the central atom, it is trans- and asymmetrical.

Re: Meaning of Cis and Trans

Posted: Sat Nov 30, 2019 1:36 pm
by Micah3J
So just to be clear, the prefixes cis and trans can be in front of any molecule that can be either symmetrical or asymmetrical?