Moderators: Chem_Mod, Chem_Admin

Ghadir Seder 1G
Posts: 134
Joined: Sat Sep 14, 2019 12:17 am


Postby Ghadir Seder 1G » Sun Dec 08, 2019 6:35 pm

Why is it that cisplatin binds to guanine bases pairs but not the other A,T, or C base pairs?

Aarushi Solanki 4F
Posts: 107
Joined: Sat Jul 20, 2019 12:17 am

Re: Cisplatin

Postby Aarushi Solanki 4F » Sun Dec 08, 2019 6:49 pm

It binds to the two consecutive N atoms' lone pairs. Each G has a nitrogen atom with a lone pair and the Cl on cisplatin is attracted to it.

Mallika Chimpiri 3K
Posts: 58
Joined: Thu Jul 25, 2019 12:17 am

Re: Cisplatin

Postby Mallika Chimpiri 3K » Sun Dec 08, 2019 7:33 pm

This is because Guanine has Nitrogens with lone pairs that bond with the Cl atoms in cisplatin.

Jacob Motawakel
Posts: 103
Joined: Wed Sep 18, 2019 12:20 am
Been upvoted: 1 time

Re: Cisplatin

Postby Jacob Motawakel » Sun Dec 08, 2019 8:06 pm

The Cl atoms in cisplatin bind to the nitrogens with lone pairs on Guanine. Also, remember that cis cisplatin structure binds stronger than trans cisplatin structure.

Return to “Naming”

Who is online

Users browsing this forum: No registered users and 2 guests