Cisplatin

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Ghadir Seder 1G
Posts: 134
Joined: Sat Sep 14, 2019 12:17 am

Cisplatin

Postby Ghadir Seder 1G » Sun Dec 08, 2019 6:35 pm

Why is it that cisplatin binds to guanine bases pairs but not the other A,T, or C base pairs?

Aarushi Solanki 4F
Posts: 107
Joined: Sat Jul 20, 2019 12:17 am

Re: Cisplatin

Postby Aarushi Solanki 4F » Sun Dec 08, 2019 6:49 pm

It binds to the two consecutive N atoms' lone pairs. Each G has a nitrogen atom with a lone pair and the Cl on cisplatin is attracted to it.

Mallika Chimpiri 3K
Posts: 58
Joined: Thu Jul 25, 2019 12:17 am

Re: Cisplatin

Postby Mallika Chimpiri 3K » Sun Dec 08, 2019 7:33 pm

This is because Guanine has Nitrogens with lone pairs that bond with the Cl atoms in cisplatin.

Jacob Motawakel
Posts: 103
Joined: Wed Sep 18, 2019 12:20 am
Been upvoted: 1 time

Re: Cisplatin

Postby Jacob Motawakel » Sun Dec 08, 2019 8:06 pm

The Cl atoms in cisplatin bind to the nitrogens with lone pairs on Guanine. Also, remember that cis cisplatin structure binds stronger than trans cisplatin structure.


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