cisplatin

[Sarah Blake-2I]

Hi! Could someone explain why the cis model in today's lecture is what forms the chemotherapy drug cisplatin? I was a little confused during the explanation of this in lecture.

[Jainam Shah 4I]

Cisplatin has the ability to form a coordination compound with DNA molecules. The 2 Cl on cisplatin bond with bases on the DNA which stop cell division which is why it makes for a good chemotherapy drug.

[Jialun Chen 4F]

The positions of the cl- ions are different between cisplatin and transplatin. For cis, the two cl- are on the same side, thus dipole moments doesn't cancel. The two Cl- thus bond with the N of the guanine base pair (forming two bonds).

[MeeraBhagat]

The cis form of the molecule has the chlorines on the same side of the cisplatin molecule, so it can effectively bind to the guanine with both chlorines stopping the cell division process and therefore eliminating cancer cells.

[Michelle Xie 2B]

Cisplatin can bind to DNA molecules and prevent cells from dividing. It is used as a treatment for cancer.