Transplatin

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Malia Shitabata 1F
Posts: 127
Joined: Sat Aug 17, 2019 12:17 am

Transplatin

Postby Malia Shitabata 1F » Fri Nov 22, 2019 12:23 am

I understand why cisplatin is an effective chemotherapy drug, but can someone reexplain why transplatin isn't? I don't think I copied it down correctly in lecture.

AprilPaz
Posts: 51
Joined: Wed Sep 18, 2019 12:18 am

Re: Transplatin

Postby AprilPaz » Fri Nov 22, 2019 2:04 am

Transplatin is not a chemotherapy drug because it cannot form a coordination compound with the DNA. Since it has its Cls on opposite sides, it cannot align with the DNA and bond.

andrewcj 2C
Posts: 102
Joined: Thu Jul 11, 2019 12:17 am

Re: Transplatin

Postby andrewcj 2C » Fri Nov 22, 2019 2:15 am

The fact that transplatin can't bind to DNA means that it doesn't stop replication, which is the purpose of chemotherapy drugs.

Kelvin Chung 1C
Posts: 50
Joined: Sat Aug 24, 2019 12:15 am

Re: Transplatin

Postby Kelvin Chung 1C » Fri Nov 22, 2019 9:19 am

Dr. Lavelle explained that since the Cls are pointing in opposite directions in the transplatin molecule, it's impossible for it to bind strongly (with both Cls as cisplatin is able to do) to DNA, hence making the transplatin unable to form a coordination complex with the DNA.


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