Cisplatin binding

Moderators: Chem_Mod, Chem_Admin

Jessica Li 4F
Posts: 115
Joined: Fri Aug 09, 2019 12:16 am

Cisplatin binding

Postby Jessica Li 4F » Fri Nov 22, 2019 1:39 pm

Can someone explain how cisplatin binds to DNA again? I understand that it binds to an exposed N atom on guanine, but do the Cl atoms then get displaced for Pt to bind to nitrogen? Also, would the bonds be intramolecular or intermolecular? Thanks!

Kylie Lim 4G
Posts: 110
Joined: Sat Aug 17, 2019 12:15 am

Re: Cisplatin binding

Postby Kylie Lim 4G » Fri Nov 22, 2019 3:51 pm

Guanine in the n7 position has an exposed nitrogen. The Cl in cisplatin will displace the nitrogen, and bond to the guanine.

Return to “Shape, Structure, Coordination Number, Ligands”

Who is online

Users browsing this forum: No registered users and 1 guest