Cisplatin and Transplatin

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Tracy Tolentino_2E
Posts: 111
Joined: Sat Sep 07, 2019 12:17 am

Cisplatin and Transplatin

Postby Tracy Tolentino_2E » Sun Nov 24, 2019 11:18 pm

How does Cisplatin stop cell division? Why doesn't Transplatin have the same effect when forming a coordinate compound with DNA?

sarahsalama2E
Posts: 143
Joined: Fri Aug 30, 2019 12:16 am

Re: Cisplatin and Transplatin

Postby sarahsalama2E » Sun Nov 24, 2019 11:22 pm

Cisplatin has the Cl atoms on the same side while trans-diamine dichloro-platinum (ii) has them located on opposite, or diagonal sides from one another. Cisplatin is a well-known chemotherapy drug that works by forming a coordinate compound with DNA. Cisplatin binds to the exposed N in guananine and binds in 2 places so that the CL atoms are displaced through 2 bonds and the DNA replication process gets blocked. Transplatin does not work in stopping cell replication because it cannot bind to the DNA in two places because the Cl are on opposite sides and cannot bind to the exposed N in guanine.

Robert Tran 1B
Posts: 92
Joined: Thu Jul 11, 2019 12:15 am

Re: Cisplatin and Transplatin

Postby Robert Tran 1B » Sun Nov 24, 2019 11:24 pm

Cisplatin stops DNA replication by bonding to two exposed guanines. This prevents the enzymes from replicating the DNA. Transplatin does not stop DNA replication because its shape only allows it to bind to one guanine. This bond is not strong enough to prevent replication.


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