Chemotheraphy Examples  [ENDORSED]

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Elizabeth Ignacio 1C
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Chemotheraphy Examples

Postby Elizabeth Ignacio 1C » Tue Dec 05, 2017 8:39 pm

The syllabus for chapter 17 on the website says we need to know "well-known examples of coordination compounds used as chemotherapy drugs." Is this something he mentioned in a lecture or something in the textbook? I can't seem to find anything on it.

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Re: Chemotheraphy Examples  [ENDORSED]

Postby Chem_Mod » Tue Dec 05, 2017 9:53 pm

I discussed cisplatin in class in detail.
Cisplatin is a chemotherapy medication used to treat many cancers.

Eli Aminpour 2K
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Re: Chemotheraphy Examples

Postby Eli Aminpour 2K » Tue Dec 05, 2017 9:56 pm

This was lectured on in class. The chemotherapy drug he referred to was Cisplatin. The long name for this drug is Cis-diamminedichloroplatinum (II), which contrasts with trans-diamminedicholoplatinum because of where the ammine or chloride groups are placed (next to or opposite of one another). Cisplatin forms a coordination compound with DNA and stops cell replication.

Mikaila 3E
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Re: Chemotheraphy Examples

Postby Mikaila 3E » Thu Dec 07, 2017 12:46 pm

Also, the cis-diamminedichloroplatinum (II) can bind better to DNA due to the location of the chlorines. The lewis structure of this compound results in the chlorines on the same side (hence the name cis-) rather than opposite sides (trans-).

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