chemotherapy example [ENDORSED]
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chemotherapy example
I'm just having a hard time understanding how the DNA bonds with the molecule. What two parts are actually bonding?
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Re: chemotherapy example
Cis platin forms a coordination compound with DNA when the two Cl's bind with two Guanine bases in DNA and these bases stop cells division. The CL's bind with the lone pair available on the nitrogen on the Guanine to form a cation. This makes the cis more effective than the trans because the trans has only one CL on each side available for binding.
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Re: chemotherapy example
I thought that for the cisplatin chemotherapy drug, when the drug is near the DNA, the 2 Chlorine atoms that are on the same side will break off from the central Pt atom. They will be replaced with 2 Nitrogen atoms found on the DNA strand. Therefore, the cisplatin is now bonded to the DNA at 2 different places. The atoms that are actually bonding are the Pt transition metal and Nitrogen on the DNA strand, forming a coordination compound.
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Re: chemotherapy example [ENDORSED]
Susu Le 1F wrote:I thought that for the cisplatin chemotherapy drug, when the drug is near the DNA, the 2 Chlorine atoms that are on the same side will break off from the central Pt atom. They will be replaced with 2 Nitrogen atoms found on the DNA strand. Therefore, the cisplatin is now bonded to the DNA at 2 different places. The atoms that are actually bonding are the Pt transition metal and Nitrogen on the DNA strand, forming a coordination compound.
This is correct. As I discussed in class the two chlorine atoms are replaced.
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Re: chemotherapy example
Yeah, as Susu said, the two Cl's dissociate form the complex and instead the coordination complex forms with lone pairs associated with the DNA. This is only possible with the cis formation of the complex because the Cl-binding locations are on the same side of the transition metal, so the DNA can physically latch on to both spots. However, in the trans formation, the binding locations will be on opposite sides of the transition metal and the DNA will only be able to attach to one of the sites (previously bonded with Cl) instead of both, making a weaker bond and weaker affect in preventing cancer proliferation.
-Andrew Evans
Secion 1G
-Andrew Evans
Secion 1G
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