Cisplatin Example

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Linh Vo 2J
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Joined: Sat Apr 28, 2018 3:00 am

Cisplatin Example

Postby Linh Vo 2J » Mon Nov 26, 2018 2:47 pm

Can someone explain to me the cisplatin example we discussed in class again? I didn’t understand how the coordination compound structure contributed to stopping cell division.

Chem_Mod
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Re: Cisplatin Example

Postby Chem_Mod » Mon Nov 26, 2018 3:02 pm

Cisplatin binds in two spots to guanine base pairs in DNA, blocking DNA replication machinery.

Joonsoo Kim 4L
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Re: Cisplatin Example

Postby Joonsoo Kim 4L » Wed Nov 28, 2018 9:19 pm

I believe that the two Cl- in cisplatin can bond with the N atoms in DNA, since the two Cl' in cisplatin are adjacent to one another (as opposed to transplatin, where they are opposite one another) and since the N atoms in DNA have lone pairs which cause it to act as a polydentate ligand. This prevents cell division from occurring since the DNA strands can no longer separate due to having bonded with the cisplatin.

Ruiting Jia 4D
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Re: Cisplatin Example

Postby Ruiting Jia 4D » Sun Dec 02, 2018 11:18 pm

it forms coordination compounds with DNA to stop cell division. I don't think we need to know the details other than that.

AvaGordon_4F
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Re: Cisplatin Example

Postby AvaGordon_4F » Sun Dec 02, 2018 11:29 pm

Yeah, like people are saying, one bond with DNA is not enough to block the DNA replication machinery. If its a trans molecule, there would only be one bond available to be made. In a cis molecule, two bonds are available to be made, and so those two bonds are what is necessary to disrupt DNA replication. Stopping DNA replication in cancer cells (which are dividing out of control) makes cisplatin a useful chemotherapy drug.

RandallNeeDis3K
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Re: Cisplatin Example

Postby RandallNeeDis3K » Fri Dec 07, 2018 1:49 am

Thank you for your help everyone!


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