Cisplatin

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sarahtang4B
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Joined: Fri Sep 28, 2018 12:27 am

Cisplatin

Postby sarahtang4B » Mon Nov 26, 2018 3:38 pm

Can somebody explain how Cisplatin works in chemotherapy again and why trans doesn't?

Chem_Mod
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Re: Cisplatin

Postby Chem_Mod » Mon Nov 26, 2018 3:43 pm

In the trans conformation, the Cl atoms do not line up to bind to DNA.

Christine Chow 4G
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Joined: Fri Sep 28, 2018 12:28 am

Re: Cisplatin

Postby Christine Chow 4G » Mon Nov 26, 2018 4:02 pm

Cisplatin has the two chlorine atoms on the same side of the molecule (vs on opposite sides). When it binds to the guanine base on the DNA molecule, a chlorine is released from cisplatin and binds to a lone pair on the guanine. Since there are two chlorines next to each other, the cisplatin can bind to two guanines next to each other and create a bond strong enough to block DNA replication. In the trans conformation, the bond isn't strong enough to prevent DNA replication. That's what I got from Lavelle's lecture, hope it helps!

Max Hayama 4K
Posts: 63
Joined: Fri Sep 28, 2018 12:16 am

Re: Cisplatin

Postby Max Hayama 4K » Mon Nov 26, 2018 8:18 pm

Does anyone know why the chlorines unbind from the ligand, and not the amine groups? Shouldn't the bond between platinum and ammonia be more prone to breaking off as opposed to the chlorine?

Camille 4I
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Joined: Sat Aug 24, 2019 12:18 am

Re: Cisplatin

Postby Camille 4I » Wed Dec 04, 2019 11:28 pm

Why is cisplatin square planar and not tetrahedral?

Brittany Tran 3I
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Joined: Sat Jul 20, 2019 12:16 am

Re: Cisplatin

Postby Brittany Tran 3I » Thu Dec 05, 2019 2:08 pm

cisplatin has two chlorine atoms next to each other, so it can bind to two guanines at a time. the nitrogen in the guanine displaces the chlorines in cisplatin, so cisplatin can bind to the guanine. this stops dna replication

005162520
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Joined: Tue Sep 24, 2019 12:17 am

Re: Cisplatin

Postby 005162520 » Sat Dec 07, 2019 10:33 am

Does chlorine get replaced by water or nitrogen from guanine base pair?

emma brinton_3B
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Joined: Fri Aug 09, 2019 12:17 am

Re: Cisplatin

Postby emma brinton_3B » Sat Dec 07, 2019 10:35 am

cisplatin works in chemotherapy as it has two Cl- atoms on one side and 2 NH3 molecules on the other side. This causes the bent shape and for cisplatin to be bidentate while transplatin would have one Cl and one NH3 on each side causing it be monodentate. The transplatin would have a harder time staying connected to DNA when the DNA polymerase attempts to replicate the DNA.

Elizabeth Harty 1A
Posts: 101
Joined: Sat Jul 20, 2019 12:16 am

Re: Cisplatin

Postby Elizabeth Harty 1A » Sat Dec 07, 2019 11:49 am

Camille 4I wrote:Why is cisplatin square planar and not tetrahedral?


its both

Elizabeth Harty 1A
Posts: 101
Joined: Sat Jul 20, 2019 12:16 am

Re: Cisplatin

Postby Elizabeth Harty 1A » Sat Dec 07, 2019 11:49 am

005162520 wrote:Does chlorine get replaced by water or nitrogen from guanine base pair?


I think the water


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