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Cisplatin

Posted: Mon Nov 26, 2018 3:38 pm
by sarahtang4B
Can somebody explain how Cisplatin works in chemotherapy again and why trans doesn't?

Re: Cisplatin

Posted: Mon Nov 26, 2018 3:43 pm
by Chem_Mod
In the trans conformation, the Cl atoms do not line up to bind to DNA.

Re: Cisplatin

Posted: Mon Nov 26, 2018 4:02 pm
by Christine Chow 4G
Cisplatin has the two chlorine atoms on the same side of the molecule (vs on opposite sides). When it binds to the guanine base on the DNA molecule, a chlorine is released from cisplatin and binds to a lone pair on the guanine. Since there are two chlorines next to each other, the cisplatin can bind to two guanines next to each other and create a bond strong enough to block DNA replication. In the trans conformation, the bond isn't strong enough to prevent DNA replication. That's what I got from Lavelle's lecture, hope it helps!

Re: Cisplatin

Posted: Mon Nov 26, 2018 8:18 pm
by Max Hayama 4K
Does anyone know why the chlorines unbind from the ligand, and not the amine groups? Shouldn't the bond between platinum and ammonia be more prone to breaking off as opposed to the chlorine?

Re: Cisplatin

Posted: Wed Dec 04, 2019 11:28 pm
by Camille 4I
Why is cisplatin square planar and not tetrahedral?

Re: Cisplatin

Posted: Thu Dec 05, 2019 2:08 pm
by Brittany Tran 3I
cisplatin has two chlorine atoms next to each other, so it can bind to two guanines at a time. the nitrogen in the guanine displaces the chlorines in cisplatin, so cisplatin can bind to the guanine. this stops dna replication

Re: Cisplatin

Posted: Sat Dec 07, 2019 10:33 am
by 005162520
Does chlorine get replaced by water or nitrogen from guanine base pair?

Re: Cisplatin

Posted: Sat Dec 07, 2019 10:35 am
by emma brinton_3B
cisplatin works in chemotherapy as it has two Cl- atoms on one side and 2 NH3 molecules on the other side. This causes the bent shape and for cisplatin to be bidentate while transplatin would have one Cl and one NH3 on each side causing it be monodentate. The transplatin would have a harder time staying connected to DNA when the DNA polymerase attempts to replicate the DNA.

Re: Cisplatin

Posted: Sat Dec 07, 2019 11:49 am
by Elizabeth Harty 1A
Camille 4I wrote:Why is cisplatin square planar and not tetrahedral?


its both

Re: Cisplatin

Posted: Sat Dec 07, 2019 11:49 am
by Elizabeth Harty 1A
005162520 wrote:Does chlorine get replaced by water or nitrogen from guanine base pair?


I think the water