cisplatin in stopping DNA replication

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Samantha Chung 4I
Posts: 77
Joined: Wed Oct 03, 2018 12:16 am

cisplatin in stopping DNA replication

Postby Samantha Chung 4I » Thu Nov 29, 2018 10:02 am

How does cisplatin function (in terms of chemistry) to stop DNA replication?

Camille Marangi 2E
Posts: 60
Joined: Fri Sep 28, 2018 12:26 am

Re: cisplatin in stopping DNA replication

Postby Camille Marangi 2E » Thu Nov 29, 2018 12:06 pm

As Lavelle explained in lecture on Monday, cisplatin is a well known chemotherapy drug. It forms a coordination compound with DNA and stops cell division through its chelating ligands. Chelates are complexes containing a ligand that forms a ring of atoms that includes the central metal atom and when these complexes bond with DNA, it stops the replication process.

Madelyn Romberg 3L
Posts: 29
Joined: Tue Oct 02, 2018 12:16 am

Re: cisplatin in stopping DNA replication

Postby Madelyn Romberg 3L » Thu Nov 29, 2018 1:21 pm

An important key to remember is the CIS part of the molecule (as a TRANS version does exist). This allows both ligands to bind to the DNA and effectively start replication whereas the TRANS version is unable to do this.

deepto_mizan1H
Posts: 65
Joined: Fri Sep 28, 2018 12:16 am

Re: cisplatin in stopping DNA replication

Postby deepto_mizan1H » Mon Dec 03, 2018 8:36 pm

In addition to the posts above, since it is a cis version of the molecule, it is also a polar molecule since the Cl groups (x2) face opposite of the NH3 groups (x2), which can be thought to let it have unique properties compared to the trans version where it would be nonpolar.


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