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Zenita Leang 2K
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Postby Zenita Leang 2K » Fri Dec 07, 2018 11:43 pm


Why is cisplatin used in chemotherapy?

Many thanks.


Ricky Ma DIS 4E
Posts: 72
Joined: Fri Sep 28, 2018 12:27 am

Re: Cisplatin

Postby Ricky Ma DIS 4E » Fri Dec 07, 2018 11:58 pm

Cis- means on the cisplatinum means that Chlorine atoms on the platinum are on the same side. This allows the cisplatinum to bind to the guanines at two parts on the DNA structure. The Nitrogens on the guanene bases replaces the Cl- on the cis platinum. This process results in the inhibition of the DNA replication.

Elaine Pham 2E
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Re: Cisplatin

Postby Elaine Pham 2E » Sat Dec 08, 2018 12:02 am

Cisplatin is used in chemotherapy for the treatment of cancer cells, which are characterized by rapid cell growth, because it can bind to DNA and prevent cell replication and thus stop cancer cells from growing. More specifically, cisplatin binds to the DNA base guanine. The nitrogens in guanine essentially replace the chlorine ligands that are attached to the transition metal in the center, platinum. The binding of cisplatin to the DNA strand then stops DNA replication and successful cell division.

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Re: Cisplatin

Postby 405169322 » Sat Dec 08, 2018 12:10 am

The Cisplatin bonds with two guanine molecules in DNA which prevents the DNA from functioning. Also if it was transplatin it would only make one bond and would not be effective.

I hope this helps :0


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