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Cis-platin , cis means that the constituents are on the same side in the structure, in this case there are 2 Cl's on one side. This is effective in chemotherapy because when cisplatin interacts with DNA, Nitrogen from the DNA takes place of Cl causing the DNA to lose its structure and function and stopping replication/uncontrollable growth.
DNA is held by hydrogen bonds. Therefore, for something to bind to it, it must also bind to a polar molecule (bonded by hydrogen bonds). Since cisplatin has its two chlorines on the same side, the dipole doesn't cancel, creating partial negative charges on the chlorines. This allows cisplatin to bind with polar DNA. In contrast, transplatin has chlorine on opposite sides, therefore the dipoles cancel and is not strong enough to bind to DNA.
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