Cisplatin

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davidryan3f
Posts: 63
Joined: Fri Sep 28, 2018 12:23 am

Cisplatin

Postby davidryan3f » Sun Dec 09, 2018 10:44 am

How does the fact that the ligands in cisplatin only bind at one site help account for the way that the drug stops cell division?

Maharsh Patel 4E
Posts: 18
Joined: Fri Sep 28, 2018 12:27 am

Re: Cisplatin

Postby Maharsh Patel 4E » Sun Dec 09, 2018 10:58 am

The cisplatin has the two chlorine atoms on the same side of the molecule, therefore, both chlorines are replaced by nitrogens in adjacent guanine base pairs. This stops the replication mechanisms from replicating the DNA because the cisplatin has stopped it.

Ashish Verma 2I
Posts: 59
Joined: Fri Sep 28, 2018 12:28 am

Re: Cisplatin

Postby Ashish Verma 2I » Sun Dec 09, 2018 10:59 am

In cisplatin the molecule is organized so that both binding sites are on the same side of the molecule so it can bind twice to the same strand of DNA stopping cell division.


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