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Shirley Liu 2I
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Joined: Fri Sep 28, 2018 12:16 am


Postby Shirley Liu 2I » Sun Dec 09, 2018 11:47 pm

Why would only cisplatin only work for chemotherapy drugs in stopping DNA transcription? would transplatin not work for DNA transcription? does it have to do with the position of the atoms and which atoms do the stopping of DNA transcription?

Posts: 34
Joined: Fri Sep 28, 2018 12:25 am

Re: Cisplatin

Postby AvaGordon_4F » Sun Dec 09, 2018 11:54 pm

Its because of the way the chlorines are oriented! They are able to bind to two relatively close guanines on DNA and bind at TWO sites, which blocks dna replication mechanisms. Transplatin isn't able to complex twice and so the one bond it makes is not enough to block replication

RoopshaChatterjee 1G
Posts: 30
Joined: Fri Sep 28, 2018 12:17 am

Re: Cisplatin

Postby RoopshaChatterjee 1G » Sun Dec 09, 2018 11:57 pm

What is the structure of cisplatin?

Posts: 30
Joined: Fri Sep 28, 2018 12:25 am

Re: Cisplatin

Postby 604656370 » Mon Dec 10, 2018 12:16 am

Its a Platinum atom bonded to two Cl atoms and 2 NH3 atoms. The cis also implies that the Cl are on the same side. At least that's what my TA said.

Josceline 3J
Posts: 33
Joined: Fri Sep 28, 2018 12:21 am

Re: Cisplatin

Postby Josceline 3J » Mon Dec 10, 2018 1:40 am

This is the first time I hear about this. I wish I had known about it sooner. Anyways thanks, everyone.

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