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Why would only cisplatin only work for chemotherapy drugs in stopping DNA transcription? would transplatin not work for DNA transcription? does it have to do with the position of the atoms and which atoms do the stopping of DNA transcription?
Its because of the way the chlorines are oriented! They are able to bind to two relatively close guanines on DNA and bind at TWO sites, which blocks dna replication mechanisms. Transplatin isn't able to complex twice and so the one bond it makes is not enough to block replication
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