Cisplatin

[Shirley Liu 2I]

Why would only cisplatin only work for chemotherapy drugs in stopping DNA transcription? would transplatin not work for DNA transcription? does it have to do with the position of the atoms and which atoms do the stopping of DNA transcription?

[AvaGordon_4F]

Its because of the way the chlorines are oriented! They are able to bind to two relatively close guanines on DNA and bind at TWO sites, which blocks dna replication mechanisms. Transplatin isn't able to complex twice and so the one bond it makes is not enough to block replication

[RoopshaChatterjee 1G]

What is the structure of cisplatin?

[604656370]

Its a Platinum atom bonded to two Cl atoms and 2 NH3 atoms. The cis also implies that the Cl are on the same side. At least that's what my TA said.

[Josceline 3J]

This is the first time I hear about this. I wish I had known about it sooner. Anyways thanks, everyone.