Cisplatin

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Fatemah Yacoub 1F
Posts: 114
Joined: Thu Jul 11, 2019 12:16 am

Cisplatin

Postby Fatemah Yacoub 1F » Wed Nov 20, 2019 1:00 pm

Can someone explain how cisplatin stops cell division?

Malia Shitabata 1F
Posts: 127
Joined: Sat Aug 17, 2019 12:17 am

Re: Cisplatin

Postby Malia Shitabata 1F » Wed Nov 20, 2019 1:19 pm

So because it is a cis molecule the two chlorine atoms are on the same side of the cisplatin molecule. As a result, when one chlorine bonds the other can be displaced so the compound can be bound in 2 places which makes the bonds stronger. This blocks DNA replication from occurring so cell division can't take place and ultimately the cell dies. This is why it's kind of dangerous in the sense that it targets both the healthy cells and cancer cells.

Maeve Miller 1A
Posts: 51
Joined: Fri Aug 09, 2019 12:16 am

Re: Cisplatin

Postby Maeve Miller 1A » Wed Nov 20, 2019 5:17 pm

This website gives a more simplistic description of cisplatin to help start to understand why the structure of cisplatin helps to kill cancer cells. Hope it helps!
https://www.netdoctor.co.uk/medicines/c ... cisplatin/

Junwei Sun 4I
Posts: 125
Joined: Wed Oct 02, 2019 12:16 am

Re: Cisplatin

Postby Junwei Sun 4I » Thu Nov 21, 2019 10:33 pm

Basically cisplatin forms a coordinate compound with the DNA strands by binding its two Chlorine atoms to DNA. Since there are two places that are bounded cisplatin bounds to DNA really tightly. When cell division happens cisplatin blocked the enzyme from going through, therefore stopping DNA replication. If DNA is not replicated then cell division cannot take place. Hope this help!

AprilPaz
Posts: 51
Joined: Wed Sep 18, 2019 12:18 am

Re: Cisplatin

Postby AprilPaz » Fri Nov 22, 2019 1:59 am

Cisplatin stops cell division because they have their Cls on the same side of cisplatin. When cisplatin is administered, the Nitrogens along the guanine will displace the Cls on the Cisplatin which causes the bond to be blocked when it is being replicated.


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