Cisplatin

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Shannon Asay 1C
Posts: 102
Joined: Fri Aug 09, 2019 12:16 am

Cisplatin

Postby Shannon Asay 1C » Sat Nov 23, 2019 4:06 pm

How does cisplatin work to stop cell division?

Anne Tsai 1F
Posts: 50
Joined: Thu Jul 25, 2019 12:15 am

Re: Cisplatin

Postby Anne Tsai 1F » Sat Nov 23, 2019 4:50 pm

Cisplatin binds to two guanine bases in DNA, allowing a HMG protein to bind and insert a phenyl group into the DNA, which creates a kink in the DNA and causes the cell to die instead of divide.

Joowon Seo 3A
Posts: 100
Joined: Sat Aug 24, 2019 12:17 am
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Re: Cisplatin

Postby Joowon Seo 3A » Sat Nov 23, 2019 5:49 pm

If you look at the cisplatin there are two Cl- ions on the same side. These Cl- ions fall out and cisplatin binds to the nitrogen in two diferent guanine base pairs. This essentially stops the enzyme from taking apart the DNA, so the cell cannot divide.


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