Cisplatin

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Fiona Latifi 1A
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Cisplatin

Postby Fiona Latifi 1A » Sat Nov 23, 2019 7:04 pm

How exactly does cisplatin stop the DNA replication of cancerous cells?

Ethan Lam 4A
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Re: Cisplatin

Postby Ethan Lam 4A » Sat Nov 23, 2019 7:09 pm

Cisplatin stops cancerous cells by stopping DNA reproduction. By having each side of the cisplatin bond with each side of DNA, it prevents the DNA from getting split and therefore copied.

Nikki Razal 1L
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Re: Cisplatin

Postby Nikki Razal 1L » Sat Nov 23, 2019 7:22 pm

^^ just to add on, Lavelle was saying how transplatin is only able to form one bond in DNA (which is weak, so it can't stop cell division), whereas cis platin is able to form 2 bonds in the DNA, causing for the DNA to be interfered with enough to the point of stopping cell division & ultimately, cell death

DHavo_1E
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Re: Cisplatin

Postby DHavo_1E » Sat Nov 23, 2019 11:15 pm

Hi,

Where does cisplatin bond on the DNA to stop translation, and thus cause the cell to die? Thanks in advance!

Nathan Nakaguchi 1G
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Re: Cisplatin

Postby Nathan Nakaguchi 1G » Sat Nov 23, 2019 11:20 pm

I believe cisplatin bonds to two nucleotides preventing the DNA to unravel itself and therefore can't be replicated.

405268063
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Re: Cisplatin

Postby 405268063 » Sun Nov 24, 2019 2:12 pm

Cisplatin, unlike transplatin, can bond to the same piece of DNA with two bonds to block DNA replication. This lack of replication can kill cancerous cells. The structure of transplatin makes it so that it can only bond at one site on DNA, which is not strong enough to stop DNA replication.

Frederick Keith_4C
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Re: Cisplatin

Postby Frederick Keith_4C » Sun Nov 24, 2019 2:18 pm

Cisplatin binds the two strands of the cell's DNA (genetic material) together, and it can't be replicated. If the strands are permanently binded together then DNA helicase won't be able to split the strands and DNA polymerase wouldn't be able to add complementary nucleotides to the lagging and leading DNA strands. So if the cell can't synthesize any more DNA then it won't be able to progress through the cell cycle and divide.

Gabriella Bates 2L
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Re: Cisplatin

Postby Gabriella Bates 2L » Sun Nov 24, 2019 2:18 pm

The Cl atoms on the clisplatin molecule bind to the exposed N on two nearby (but not necessarily next to each other) guanine nucleotides, forming a coordination compound with the DNA molecule. The bound cisplatin blocks DNA replication machinery, preventing the DNA from replicating and ultimately stopping cell division.

Sadhana_Dicussion_4A
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Re: Cisplatin

Postby Sadhana_Dicussion_4A » Sun Nov 24, 2019 2:24 pm

Cisplatin works by attaching itself to DNA in a way that prohibits its function. It bonds to the guanine and adenine bases so the water molecules originally bound to the platinum fall off, and coordinate covalent bonds to the platinum are formed using a lone pair on the nitrogen atom of two guanines next to each other on the helix. This disrupts the helix and prevents the DNA from replicating.

Nathan Rothschild_2D
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Joined: Fri Aug 02, 2019 12:15 am

Re: Cisplatin

Postby Nathan Rothschild_2D » Sun Nov 24, 2019 3:18 pm

Where can I find this in the book so I can read more on it?

Emily_4B
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Re: Cisplatin

Postby Emily_4B » Sun Nov 24, 2019 3:26 pm

would we need to know this on the final?

Fiona Latifi 1A
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Re: Cisplatin

Postby Fiona Latifi 1A » Sat Nov 30, 2019 8:40 am

Emily_4B wrote:would we need to know this on the final?


Yes, you should know it for the final.

Emily_4B
Posts: 57
Joined: Wed Sep 18, 2019 12:21 am

Re: Cisplatin

Postby Emily_4B » Sat Nov 30, 2019 3:45 pm

Fiona Latifi 1B wrote:
Emily_4B wrote:would we need to know this on the final?


Yes, you should know it for the final.

Got it thanks

MeeraBhagat
Posts: 95
Joined: Sat Aug 24, 2019 12:15 am

Re: Cisplatin

Postby MeeraBhagat » Sun Dec 01, 2019 12:23 pm

DHavo_3H wrote:Hi,

Where does cisplatin bond on the DNA to stop translation, and thus cause the cell to die? Thanks in advance!


The chlorines in the cisplatin bind to the guanines in the DNA strand to stop replication.

Edmund Zhi 2B
Posts: 118
Joined: Sat Jul 20, 2019 12:16 am

Re: Cisplatin

Postby Edmund Zhi 2B » Mon Dec 02, 2019 12:22 am

Are we going to have to apply this knowledge for the final or do we just have to memorize it?

Varadhan_3G
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Joined: Wed Sep 18, 2019 12:20 am

Re: Cisplatin

Postby Varadhan_3G » Mon Dec 02, 2019 1:18 am

If you memorize why cisplatin is able to stop DNA replication, and by extension cell division, you should also be able to apply this information to the final. I feel like in the context of the final, the application and memorization of this information is more or less synonymous.


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