Cisplatin

[Fiona Latifi 1A]

How exactly does cisplatin stop the DNA replication of cancerous cells?

[Ethan Lam 4A]

Cisplatin stops cancerous cells by stopping DNA reproduction. By having each side of the cisplatin bond with each side of DNA, it prevents the DNA from getting split and therefore copied.

[Nikki Razal 1L]

^^ just to add on, Lavelle was saying how transplatin is only able to form one bond in DNA (which is weak, so it can't stop cell division), whereas cis platin is able to form 2 bonds in the DNA, causing for the DNA to be interfered with enough to the point of stopping cell division & ultimately, cell death

[DHavo_1E]

Hi,

Where does cisplatin bond on the DNA to stop translation, and thus cause the cell to die? Thanks in advance!

[Nathan Nakaguchi 1G]

I believe cisplatin bonds to two nucleotides preventing the DNA to unravel itself and therefore can't be replicated.

[405268063]

Cisplatin, unlike transplatin, can bond to the same piece of DNA with two bonds to block DNA replication. This lack of replication can kill cancerous cells. The structure of transplatin makes it so that it can only bond at one site on DNA, which is not strong enough to stop DNA replication.

[Frederick Keith_4C]

Cisplatin binds the two strands of the cell's DNA (genetic material) together, and it can't be replicated. If the strands are permanently binded together then DNA helicase won't be able to split the strands and DNA polymerase wouldn't be able to add complementary nucleotides to the lagging and leading DNA strands. So if the cell can't synthesize any more DNA then it won't be able to progress through the cell cycle and divide.

[Gabriella Bates 2L]

The Cl atoms on the clisplatin molecule bind to the exposed N on two nearby (but not necessarily next to each other) guanine nucleotides, forming a coordination compound with the DNA molecule. The bound cisplatin blocks DNA replication machinery, preventing the DNA from replicating and ultimately stopping cell division.

[Sadhana_Dicussion_4A]

Cisplatin works by attaching itself to DNA in a way that prohibits its function. It bonds to the guanine and adenine bases so the water molecules originally bound to the platinum fall off, and coordinate covalent bonds to the platinum are formed using a lone pair on the nitrogen atom of two guanines next to each other on the helix. This disrupts the helix and prevents the DNA from replicating.

[Nathan Rothschild_2D]

Where can I find this in the book so I can read more on it?

[Emily_4B]

would we need to know this on the final?

[Fiona Latifi 1A]

would we need to know this on the final?

Yes, you should know it for the final.

[Emily_4B]

would we need to know this on the final?

Yes, you should know it for the final.

Got it thanks

[MeeraBhagat]

Hi,

Where does cisplatin bond on the DNA to stop translation, and thus cause the cell to die? Thanks in advance!

The chlorines in the cisplatin bind to the guanines in the DNA strand to stop replication.

[Edmund Zhi 2B]

Are we going to have to apply this knowledge for the final or do we just have to memorize it?

[Varadhan_3G]

If you memorize why cisplatin is able to stop DNA replication, and by extension cell division, you should also be able to apply this information to the final. I feel like in the context of the final, the application and memorization of this information is more or less synonymous.