Cisplatin

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Doris Cho 1D
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Joined: Thu Jul 11, 2019 12:16 am

Cisplatin

Postby Doris Cho 1D » Sun Nov 24, 2019 6:40 pm

I'm still not quite sure the concept of cisplatin, like what do we need to know about it? Can someone give me a brief explanation of its importance?

Michelle Song 1I
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Joined: Thu Jul 11, 2019 12:17 am

Re: Cisplatin

Postby Michelle Song 1I » Sun Nov 24, 2019 7:42 pm

Cisplatin is used in a certain kind of chemotherapy. It stops DNA from replicating by binding onto the guanine residues. It can only bind when the DNA is replicating, which is usually DNA in cancer cells. However, it can also affect healthy cells with replicating DNA.

claudia_1h
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Joined: Fri Aug 09, 2019 12:16 am

Re: Cisplatin

Postby claudia_1h » Sun Nov 24, 2019 7:46 pm

I don't fully understand the concept yet, but in lecture, Dr. Lavelle said we need to "know how cisplatin shuts down cell division." I'm assuming this means we need to understand that cisplatin (and NOT trans-diamine-dichloro-platinum" has the correct geometry to form a coordination compound with DNA, which effectively stops the cell division. That's the basic concept, but more detail may be needed.

ashwathinair
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Re: Cisplatin

Postby ashwathinair » Sun Nov 24, 2019 8:01 pm

You should know cisplatin has a different structure than the trans version of the molecule because of sigma and pi bonds and the lewis structures of each.

ATingin_3I
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Joined: Fri Aug 30, 2019 12:17 am

Re: Cisplatin

Postby ATingin_3I » Sun Nov 24, 2019 8:46 pm

ashwathinair wrote:You should know cisplatin has a different structure than the trans version of the molecule because of sigma and pi bonds and the lewis structures of each.


so what would transplatin be used for?

Helen Struble 2F
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Joined: Sat Aug 24, 2019 12:17 am

Re: Cisplatin

Postby Helen Struble 2F » Sun Nov 24, 2019 9:10 pm

I think the important thing about cisplatin is the way its structure affects its biological function. Because the two chlorine atoms are next to each other instead of across, they can bond to both sides of DNA's double helix, preventing it from "unzipping" and therefore stopping replication. This would be impossible in with a trans configuration.

Michelle Song 1I
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Joined: Thu Jul 11, 2019 12:17 am

Re: Cisplatin

Postby Michelle Song 1I » Tue Nov 26, 2019 4:05 pm

ATingin_3I wrote:
ashwathinair wrote:You should know cisplatin has a different structure than the trans version of the molecule because of sigma and pi bonds and the lewis structures of each.


so what would transplatin be used for?


Nothing in particular

Abby Soriano 1J
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Joined: Sat Aug 24, 2019 12:16 am

Re: Cisplatin

Postby Abby Soriano 1J » Tue Nov 26, 2019 4:24 pm

Cisplatin is important because its two Cl ligands are on the same side. When it comes into contact with DNA, the two Cl's are displaced by the exposed N's on guanine, resulting in a strong bond that essentially stops all cell division and makes cisplatin useful as a chemotherapy drug.

Juana Abana 1G
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Joined: Wed Sep 18, 2019 12:15 am

Re: Cisplatin

Postby Juana Abana 1G » Sun Dec 01, 2019 9:00 pm

Helen Struble 3B wrote:I think the important thing about cisplatin is the way its structure affects its biological function. Because the two chlorine atoms are next to each other instead of across, they can bond to both sides of DNA's double helix, preventing it from "unzipping" and therefore stopping replication. This would be impossible in with a trans configuration.


Ohh okay this makes sense. Thank you.

505316964
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Re: Cisplatin

Postby 505316964 » Sun Dec 01, 2019 10:18 pm

is cisplatin a chelate?

Hannah Romano 4D
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Joined: Sat Aug 24, 2019 12:18 am

Re: Cisplatin

Postby Hannah Romano 4D » Sun Dec 01, 2019 10:23 pm

cisplatin works to shut down cell division because it binds to the DNA at two nearby guanines such that the DNA cannot be "unzipped" for DNA replication. If the DNA can't replicate then cell division can no longer occur and the cell will just eventually die.

Erik Buetow 1F
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Joined: Fri Aug 30, 2019 12:15 am

Re: Cisplatin

Postby Erik Buetow 1F » Sun Dec 01, 2019 10:50 pm

Cisplatin prohibits cell division. I think the importance of it is that it can be used as a chemotherapy treatment and also the "trans" version of this drug would not effectively treat cancer in the same way due to the arrangement of the elements.

Trent Yamamoto 2J
Posts: 111
Joined: Sat Aug 17, 2019 12:18 am

Re: Cisplatin

Postby Trent Yamamoto 2J » Sun Dec 01, 2019 11:02 pm

Cisplatin is a chemotherapy drug that stops cell division by forming a coordination compound with DNA by bonding with the N7 Guanine lone pair. It is important to note that Transplatin does not have the same effect because the Cl's are on opposite sides.


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