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Cisplatin is used in a certain kind of chemotherapy. It stops DNA from replicating by binding onto the guanine residues. It can only bind when the DNA is replicating, which is usually DNA in cancer cells. However, it can also affect healthy cells with replicating DNA.
I don't fully understand the concept yet, but in lecture, Dr. Lavelle said we need to "know how cisplatin shuts down cell division." I'm assuming this means we need to understand that cisplatin (and NOT trans-diamine-dichloro-platinum" has the correct geometry to form a coordination compound with DNA, which effectively stops the cell division. That's the basic concept, but more detail may be needed.
I think the important thing about cisplatin is the way its structure affects its biological function. Because the two chlorine atoms are next to each other instead of across, they can bond to both sides of DNA's double helix, preventing it from "unzipping" and therefore stopping replication. This would be impossible in with a trans configuration.
ATingin_3I wrote:ashwathinair wrote:You should know cisplatin has a different structure than the trans version of the molecule because of sigma and pi bonds and the lewis structures of each.
so what would transplatin be used for?
Nothing in particular
Cisplatin is important because its two Cl ligands are on the same side. When it comes into contact with DNA, the two Cl's are displaced by the exposed N's on guanine, resulting in a strong bond that essentially stops all cell division and makes cisplatin useful as a chemotherapy drug.
Helen Struble 3B wrote:I think the important thing about cisplatin is the way its structure affects its biological function. Because the two chlorine atoms are next to each other instead of across, they can bond to both sides of DNA's double helix, preventing it from "unzipping" and therefore stopping replication. This would be impossible in with a trans configuration.
Ohh okay this makes sense. Thank you.
cisplatin works to shut down cell division because it binds to the DNA at two nearby guanines such that the DNA cannot be "unzipped" for DNA replication. If the DNA can't replicate then cell division can no longer occur and the cell will just eventually die.
Cisplatin prohibits cell division. I think the importance of it is that it can be used as a chemotherapy treatment and also the "trans" version of this drug would not effectively treat cancer in the same way due to the arrangement of the elements.
Cisplatin is a chemotherapy drug that stops cell division by forming a coordination compound with DNA by bonding with the N7 Guanine lone pair. It is important to note that Transplatin does not have the same effect because the Cl's are on opposite sides.
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