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I got this online and hope it answers your question. "Cisplatin molecules are known to be attacked by water molecules before they react with DNA. ... 3) When cis-form of (NH3)2 Pt 2+ reacts with two Guanines in DNA, the two N atoms in Guanines can readily bind to the Pt atom in cisplatin. The transplatin due to steric reasons does not provide that opportunity."
While I don't think we need to know this aspect of the chemo drug because Lavelle did not really mention it, I think it's because the energy cost associated with using cisplatin is a lot lower than using transplatin. Also, I think the structure of cisplatin makes it able to actually bind to the Gs and stop DNA replication while translplatin cannot.
I believe it is because cisplatin has the chlorines pointing in the same general direction, so cisplatin can bond more strongly to DNA, whereas transplatin can only bind to the DNA on one site at a time and can easily be removed off of the DNA strand.
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