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Postby kpang_4H » Sun Nov 24, 2019 10:04 pm

Why cisplatin is used for chemotherapy and not transplatin?

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Re: Cisplatin

Postby saigorijavolu2k » Sun Nov 24, 2019 10:09 pm

Cisplatin attacks the dna of the cancer cells and inhibits their repair. Transplatin cannot do that.

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Re: Cisplatin

Postby JohannaPerezH2F » Sun Nov 24, 2019 10:10 pm

I got this online and hope it answers your question. "Cisplatin molecules are known to be attacked by water molecules before they react with DNA. ... 3) When cis-form of (NH3)2 Pt 2+ reacts with two Guanines in DNA, the two N atoms in Guanines can readily bind to the Pt atom in cisplatin. The transplatin due to steric reasons does not provide that opportunity."

Karyn How 1J
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Re: Cisplatin

Postby Karyn How 1J » Sun Nov 24, 2019 10:11 pm

I think it's due to the fact that cisplatin is polar and transplatin is nonpolar. The polarity probably impacts the cancer cells and is more effective in chemotherapy.

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Re: Cisplatin

Postby Ananta3G » Sun Nov 24, 2019 10:17 pm

While I don't think we need to know this aspect of the chemo drug because Lavelle did not really mention it, I think it's because the energy cost associated with using cisplatin is a lot lower than using transplatin. Also, I think the structure of cisplatin makes it able to actually bind to the Gs and stop DNA replication while translplatin cannot.

Areena H 2K
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Re: Cisplatin

Postby Areena H 2K » Sun Nov 24, 2019 10:26 pm

I think its due to the fact that cisplatin can bind 2 regions of the DNA and block cell replication. Even though it has side effects such as killing normal cells, it does effectively kill the cancer cells.

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Re: Cisplatin

Postby Chantel_2I » Mon Nov 25, 2019 9:08 pm

I believe it is because cisplatin has the chlorines pointing in the same general direction, so cisplatin can bond more strongly to DNA, whereas transplatin can only bind to the DNA on one site at a time and can easily be removed off of the DNA strand.

Quynh Vo
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Re: Cisplatin

Postby Quynh Vo » Tue Nov 26, 2019 12:12 pm

cisplatin is more efficient to bonding to cells because of its structure

Doreen Liu 4D
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Re: Cisplatin

Postby Doreen Liu 4D » Tue Nov 26, 2019 2:33 pm

Its structure helps it to bind to DNA molecules and prevent replication.

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