Cisplatin

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Alvaro Chumpitaz 4D
Posts: 56
Joined: Wed Sep 11, 2019 12:17 am

Cisplatin

Postby Alvaro Chumpitaz 4D » Sun Dec 01, 2019 3:32 pm

Hi can someone explain what we needs to know about cisplatin for the final?

005162902
Posts: 102
Joined: Wed Sep 18, 2019 12:15 am

Re: Cisplatin

Postby 005162902 » Sun Dec 01, 2019 4:11 pm

I would say we need to know that its a coordination compound and the structure (why its cis vs trans). Then I would also know its biological significance as a chemotherapy drug. It is used to stop DNA replication of cancerous cells. The chlorines in cisplatin bind to the guanines in the DNA strand, stopping replication thus preventing cancer from spreading.

pauline young 1L
Posts: 50
Joined: Thu Jul 11, 2019 12:15 am

Re: Cisplatin

Postby pauline young 1L » Sun Dec 01, 2019 4:20 pm

I remember Dr. Lavelle mentioning how we should know how the cisplatin works, but i don't think we need to know anything more than the extent of what is mentioned above ^

Deena Doan 2F
Posts: 100
Joined: Sat Aug 17, 2019 12:17 am

Re: Cisplatin

Postby Deena Doan 2F » Sun Dec 01, 2019 7:29 pm

There is a possibility we might have to know the structure of it as well because I think I read it somewhere on Bruinwalk.

Sean Tran 2K
Posts: 65
Joined: Sat Aug 17, 2019 12:17 am

Re: Cisplatin

Postby Sean Tran 2K » Sun Dec 01, 2019 8:19 pm

I thought the only thing regarding the structure of cisplatin we needed to remember was what side the Cl atoms were on.

005162520
Posts: 101
Joined: Tue Sep 24, 2019 12:17 am

Re: Cisplatin

Postby 005162520 » Sun Dec 01, 2019 8:27 pm

Do we need to know why the chlorines bind to the guanines of the DNA strand?


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