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Posted: Mon Dec 02, 2019 10:45 pm
can someone explain the cisplatin example again please
Posted: Mon Dec 02, 2019 11:44 pm
The cisplatin example in class discussed the difference between cis-diamine-dichloro-platinum(II) and trans-diamine-dichloro-platinum(II). The cisplatin has two cl's on the left of the central atom (Pt) and two NH3's on the right of the central atom. The Transplatin (not exactly sure if that is how you say it) had the Cl's diagonal from one another and the NH3's also diagonal from one another. Cisplatin is used as a chemotherapy drug to stop cell division. Its shape is able to help it do this because the two Cl's on the same side can attach to DNA and inhibit it from replicating. The Transplatin can not do this because its Cl's are on opposite sides.
Posted: Mon Dec 02, 2019 11:47 pm
I agree with the answer above. It's also one of the biological examples Dr. Lavelle expects us to memorize.
Posted: Tue Dec 03, 2019 12:50 pm
How do the Cl atoms attach to the DNA?
Posted: Tue Dec 03, 2019 12:51 pm
The Cl atoms don't directly attach to the DNA. The Cl atoms are replaced by nitrogen atoms when the cisplatin binds to guanine on the DNA. This is now going into too much depth. Just know its general function.
Posted: Tue Dec 03, 2019 5:01 pm
I have heard on past chem finals, students have had to draw cisplatin. So maybe be familiar with the chemical formula and shape.