Cisplatin

Moderators: Chem_Mod, Chem_Admin

Siddiq 1E
Posts: 106
Joined: Fri Aug 09, 2019 12:15 am

Cisplatin

Postby Siddiq 1E » Wed Dec 04, 2019 9:27 am

I'm a little bit confused as to how the structure of cisplatin allows it to act as a chemotherapeutic agent.


Wendy 1E
Posts: 111
Joined: Sat Aug 17, 2019 12:17 am
Been upvoted: 2 times

Re: Cisplatin

Postby Wendy 1E » Wed Dec 04, 2019 10:05 am

Unlike trans-diamine-dichloro-platinum, Cisplatin has two Cls on the same side of the molecule that allows the Cls to bind to the same DNA strand to form 2 bonds. This blocks the enzymes used in DNA replication from replicating the DNA strand. Thus, it blocks DNA replication.

Sanjana Borle 2K
Posts: 111
Joined: Fri Aug 09, 2019 12:15 am

Re: Cisplatin

Postby Sanjana Borle 2K » Wed Dec 04, 2019 2:39 pm

Why is ciplatin square planar and not tetrahedral?

Deana Moghaddas 3E
Posts: 51
Joined: Fri Aug 30, 2019 12:17 am

Re: Cisplatin

Postby Deana Moghaddas 3E » Wed Dec 04, 2019 2:43 pm

Do we have to know that for the test?

Sanjana Borle 2K
Posts: 111
Joined: Fri Aug 09, 2019 12:15 am

Re: Cisplatin

Postby Sanjana Borle 2K » Wed Dec 04, 2019 2:45 pm

I think we do, because he talked about the different structures that coordination compounds can have, like tetrahedral, octahedral, square planar.

Milisuryani Santoso 1L
Posts: 44
Joined: Thu Jul 11, 2019 12:15 am

Re: Cisplatin

Postby Milisuryani Santoso 1L » Wed Dec 04, 2019 8:43 pm

Also, it's good to remember how to draw it, just in case. Plus it helps with labelling its molecular shape and usage for chemotherapy.


Return to “Biological Examples”

Who is online

Users browsing this forum: No registered users and 2 guests