Cisplatin

[Siddiq 1E]

I'm a little bit confused as to how the structure of cisplatin allows it to act as a chemotherapeutic agent.

[Abhi Vempati 2H]

viewtopic.php?f=47&t=54235&p=200584&hilit=cisplatin&sid=a21d2330bf22d2b242277ad29b7fb59a#p200584

Hope this helps!

[Wendy 1E]

Unlike trans-diamine-dichloro-platinum, Cisplatin has two Cls on the same side of the molecule that allows the Cls to bind to the same DNA strand to form 2 bonds. This blocks the enzymes used in DNA replication from replicating the DNA strand. Thus, it blocks DNA replication.

[Sanjana Borle 2K]

Why is ciplatin square planar and not tetrahedral?

[Deana Moghaddas 3E]

Do we have to know that for the test?

[Sanjana Borle 2K]

I think we do, because he talked about the different structures that coordination compounds can have, like tetrahedral, octahedral, square planar.

[Milisuryani Santoso 1L]

Also, it's good to remember how to draw it, just in case. Plus it helps with labelling its molecular shape and usage for chemotherapy.