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Cisplatin

Posted: Wed Dec 04, 2019 9:27 am
by Siddiq 1E
I'm a little bit confused as to how the structure of cisplatin allows it to act as a chemotherapeutic agent.

Re: Cisplatin

Posted: Wed Dec 04, 2019 9:29 am
by Abhi Vempati 2H

Re: Cisplatin

Posted: Wed Dec 04, 2019 10:05 am
by Wendy 1E
Unlike trans-diamine-dichloro-platinum, Cisplatin has two Cls on the same side of the molecule that allows the Cls to bind to the same DNA strand to form 2 bonds. This blocks the enzymes used in DNA replication from replicating the DNA strand. Thus, it blocks DNA replication.

Re: Cisplatin

Posted: Wed Dec 04, 2019 2:39 pm
by Sanjana Borle 2K
Why is ciplatin square planar and not tetrahedral?

Re: Cisplatin

Posted: Wed Dec 04, 2019 2:43 pm
by Deana Moghaddas 3E
Do we have to know that for the test?

Re: Cisplatin

Posted: Wed Dec 04, 2019 2:45 pm
by Sanjana Borle 2K
I think we do, because he talked about the different structures that coordination compounds can have, like tetrahedral, octahedral, square planar.

Re: Cisplatin

Posted: Wed Dec 04, 2019 8:43 pm
by Milisuryani Santoso 1L
Also, it's good to remember how to draw it, just in case. Plus it helps with labelling its molecular shape and usage for chemotherapy.