Cisplatin binding

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Anisha Chandra 1K
Posts: 118
Joined: Thu Jul 11, 2019 12:17 am

Cisplatin binding

Postby Anisha Chandra 1K » Thu Dec 05, 2019 2:53 pm

How does the lone pair of the guanine bind to cisplatin? Does it bind to the chlorines of cisplatin? Or is the chlorine displaced by nitrogen or water?

Indy Bui 1l
Posts: 99
Joined: Sat Sep 07, 2019 12:19 am

Re: Cisplatin binding

Postby Indy Bui 1l » Thu Dec 05, 2019 3:30 pm

The two chlorines in cisplatin get replaced by Water which bonds to the nitrogen lone pairs on two guanines. I believe these are hydrogen bonds with the Oxygen facing towards the Platinum

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