Cisplatin H2O

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KDang_1D
Posts: 127
Joined: Fri Aug 30, 2019 12:15 am
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Cisplatin H2O

Postby KDang_1D » Fri Dec 06, 2019 1:07 am

I was wondering how cisplatin binds to DNA since Cl doesn't typically form coordinating covalent bonds. Google says that the Cl is replaced with H2O. What drives this process?

405335722
Posts: 56
Joined: Fri Aug 30, 2019 12:16 am

Re: Cisplatin H2O

Postby 405335722 » Fri Dec 06, 2019 11:11 am

there is a whole explanation in the book in topic 9C!!

the book says the chlorine gets replaced with water so the hydrogens can form H bonds with the lone pair on nitrogen in Guanine but dr lavelle just said that the chlorine gets replaced by the nitrogen in guanine

i dont think we will have to know that specific though

Sanjana Borle 2K
Posts: 111
Joined: Fri Aug 09, 2019 12:15 am

Re: Cisplatin H2O

Postby Sanjana Borle 2K » Fri Dec 06, 2019 11:13 am

I think the most we will have to know about cisplatin is how to draw it and why it is used as a chemotherapy drug whereas trans platin is not.


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