cisplatin vs transplatin?

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Alfred Barrion 2H
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Joined: Sat Jul 20, 2019 12:16 am

cisplatin vs transplatin?

Postby Alfred Barrion 2H » Sat Dec 07, 2019 3:39 pm

Whats the difference between cisplatin and transplatin?

Ethan Lam 4A
Posts: 69
Joined: Thu Jul 11, 2019 12:17 am

Re: cisplatin vs transplatin?

Postby Ethan Lam 4A » Sat Dec 07, 2019 3:41 pm

Cisplatin has the Cl atoms on the same side while transplatin has them on opposite sides. By having Cl on the same side, cisplatin is able to block DNA.

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Joined: Thu Jul 25, 2019 12:16 am

Re: cisplatin vs transplatin?

Postby Megan_1F » Sat Dec 07, 2019 5:05 pm

Cisplatin has the Cl on the same sides, making it stronger when it attaches to the nitrogen base of Guanine in the DNA double helix. This double attachment of chlorine will block DNA replication and thus prevent cell division.

Transplatin will only have one chlorine to bind to on one side and will not be strong enough to block DNA replication.

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