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Cisplatin

Posted: Sat Dec 07, 2019 11:08 pm
by Angelo Mapalo 4E
Why can the cis- version of the complex form 2 bonds and why can the trans- version of the complex only form 1 bond?

Re: Cisplatin

Posted: Sat Dec 07, 2019 11:13 pm
by 505306205
Cis can form two bonds because the Chlorines are on the same side, while in trans they are opposite of each other.

Re: Cisplatin

Posted: Sun Dec 08, 2019 12:22 am
by Martina
The chlorines are on the same side and bind to DNA twice, which stops cell division.

Re: Cisplatin

Posted: Sun Dec 08, 2019 1:11 am
by Kyle Thorin
In the cis- molecule, the Chlorines are on the same side so they are both able to bind to adjacent Guanines on a DNA strip. in transplatin the Cl will be on opposite side, so only one Cl will be able to bond with the Guanine.

Re: Cisplatin

Posted: Sun Dec 08, 2019 1:17 am
by selatran1h
In the cis- molecule, the chlorines occur on the same side. In the trans- molecule, chlorine occurs on the opposite side

Re: Cisplatin

Posted: Sun Dec 08, 2019 1:54 am
by Anna Heckler 2C
In the cis-molecule, the chlorines are on the same side. They bond to adjacent guanines by kicking off a nitrogen on a DNA molecule. The trans-platin version of the molecule has Cl's oriented on opposite sides, so when one of the Cl's binds to a guanine, the DNA Polymerase can easily kick off the Cl and continue DNA replication.