Cisplatin Bonding

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Brennan McGurrr 3C
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Joined: Wed Sep 30, 2020 9:47 pm

Cisplatin Bonding

Postby Brennan McGurrr 3C » Sun Nov 29, 2020 9:49 pm

Can cisplatin bond to any other nitrogenous bases other than guanine, or do there have to be two guanines in a row for it to bond to the DNA strand?

Blake Ballew 1H
Posts: 90
Joined: Wed Sep 30, 2020 9:35 pm

Re: Cisplatin Bonding

Postby Blake Ballew 1H » Sun Nov 29, 2020 10:07 pm

No I think it can bond to any other molecule with a similar nitrogenous base. Guanine is just a relevant example.

Griffin G
Posts: 89
Joined: Wed Sep 30, 2020 9:50 pm

Re: Cisplatin Bonding

Postby Griffin G » Sun Nov 29, 2020 11:52 pm

I'm pretty sure the only place it can bond to in a dna strand is two guanines, and that's why Lavelle named it something-to-do-with-guanine inhibitor.

Aaron Akhavan-Dis1B
Posts: 94
Joined: Wed Sep 30, 2020 9:59 pm

Re: Cisplatin Bonding

Postby Aaron Akhavan-Dis1B » Sun Nov 29, 2020 11:56 pm

As long as the 2 nitrogen have lone pairs in 2 base pairs, then the cisplatin can bond and get rid of the Cl. It may be that 2 guanines are needed because if it were only 1 guanine it would be weak and enzyme reading the base pairs would just overpower the Cisplatin.

Samudrala_Vaishnavi 3A
Posts: 93
Joined: Wed Sep 30, 2020 9:34 pm

Re: Cisplatin Bonding

Postby Samudrala_Vaishnavi 3A » Mon Nov 30, 2020 8:11 am

There have to be two guanines in a row to allows for a stronger bond to form between the cisplatin's two Cl atoms rather than have one bond form between them. Guanines have a special structure that allows them to bond to the ligand in that way. This GGCC pattern tends to be a common one in all biological organisms to aid in the DNA's durability.


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