Cisplatin Bonding

[Brennan McGurrr 3C]

Can cisplatin bond to any other nitrogenous bases other than guanine, or do there have to be two guanines in a row for it to bond to the DNA strand?

[Blake Ballew 1H]

No I think it can bond to any other molecule with a similar nitrogenous base. Guanine is just a relevant example.

[Griffin G]

I'm pretty sure the only place it can bond to in a dna strand is two guanines, and that's why Lavelle named it something-to-do-with-guanine inhibitor.

[Aaron Akhavan-Dis1B]

As long as the 2 nitrogen have lone pairs in 2 base pairs, then the cisplatin can bond and get rid of the Cl. It may be that 2 guanines are needed because if it were only 1 guanine it would be weak and enzyme reading the base pairs would just overpower the Cisplatin.

[Samudrala_Vaishnavi 3A]

There have to be two guanines in a row to allows for a stronger bond to form between the cisplatin's two Cl atoms rather than have one bond form between them. Guanines have a special structure that allows them to bond to the ligand in that way. This GGCC pattern tends to be a common one in all biological organisms to aid in the DNA's durability.