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As long as the 2 nitrogen have lone pairs in 2 base pairs, then the cisplatin can bond and get rid of the Cl. It may be that 2 guanines are needed because if it were only 1 guanine it would be weak and enzyme reading the base pairs would just overpower the Cisplatin.
There have to be two guanines in a row to allows for a stronger bond to form between the cisplatin's two Cl atoms rather than have one bond form between them. Guanines have a special structure that allows them to bond to the ligand in that way. This GGCC pattern tends to be a common one in all biological organisms to aid in the DNA's durability.
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